Detail Cantuman Kembali
Sintesis Senyawa N-(4-Hidroksifenil)Benzamida Dan Uji Aktivitas Analgesiknya Pada Mencit (Mus Musculus)
- Bagikan:
To develop the new drug of analgesic-antipyretics group in this research, preparation of N-(4-hydroxyphenyl)benzamide had been done by reaction of p¬aminophenol and benzoyl chloride. The N-(4-hydroxyphenyl) benzamide prepared by solvent-modified Schotten-Baumann method was 51,00% and its melting point was 200-202°C. The compound was identified using the spectrophotometric data of ultraviolet and infrared, and nuclear magnetic resonance spectroscopic.
The analgesic activity was tested using writhing test method. The result showed that in dose 25 mg/kg mice body-weight, the pain-inhibition percentage of N-(4-hydroxyphenyl) benzamide was 17,6%, in dose 50 mg/kg mice body-weight was 34,3% and in dose 100 mg/kg mice body weight was 54,1%. However, the standard compound paracetamol in dose 25 mg/kg mice body-weight, the pain-inhibition percentage was 15,3%, in dose 50 mg/kg mice body-weight was 32,0%, and in dose 100 mg/kg mice body-weight was 52,3%. Based on datas of pain-inhibition percentage concluded that N-(4-hydroxyphenyl)benzamide had analgesic activity and was higher than paracetamol.
Sari, Novieta Maya - Personal Name
6B.S Sar s
6B.S Sar s
Text
Indonesia
Fakultas Farmasi UNAIR
2009
Surabaya
xiii; 65p.; 30cm
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